Arizona Cardinals
San Francisco 49ersPrediction markets make San Francisco 49ers the favorite at -376.
See the full NFL board & lines →Where this game is priced right now. Every number is peer to peer, so there is no house margin in it.
San Francisco is a 14.5-point favorite, and the moneyline at -1011 reflects just how lopsided this matchup looks on paper. Arizona is listed at +133 to pull the outright upset. Neither side has a BettorEdge price posted yet, so the board is open for the community to come in and set their own number, which is exactly what a peer-to-peer marketplace is built for.
A 14.5-point spread is a statement. The market is treating this less like a game and more like a formality for San Francisco at home. For Arizona backers, the +133 outright price offers real return if they believe in the upset, and that number can be beat if someone posts a better line on BettorEdge before kickoff.
No props are in the feed yet for this game. As the week progresses and the BettorEdge community starts posting, player props on a spread this wide tend to attract sharp positioning on the underdog's individual performers. Check the board closer to Sunday and use the open-interest data to see where real money is landing.
With no BettorEdge prices posted on either side, this is a prime spot to set your own line and let the community trade against you. The Cardinals at +133 fair market value is the only number with any outright appeal, and if you can post a number above that on BettorEdge, you are ahead before the ball is kicked. The peer-to-peer structure means no vig eating into your return either way.
Arizona Cardinals and San Francisco 49ers last played on Sunday, Nov 16, 2025, when the San Francisco 49ers won 41–22. The last 4 meetings are split 2-2.
SFSan Francisco 49ers@ARIArizona Cardinals41–22SFARIArizona Cardinals@SFSan Francisco 49ers15–16SFSFSan Francisco 49ers@ARIArizona Cardinals24–47ARIARIArizona Cardinals@SFSan Francisco 49ers24–23ARINext scheduled meeting: Arizona Cardinals at San Francisco 49ers on Sep 27, 2026 at 4:05 PM ET. Lines post as the game approaches.
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Arizona Cardinals at San Francisco 49ers kicks off Sunday, Sep 27, 4:05 PM ET. Start times are listed in Eastern; check your own zone if you are watching from elsewhere. Live odds and player props for the game are on this page.
The favorite is whichever side lays points on the spread and carries the shorter moneyline on the board above. BettorEdge shows the live peer-to-peer price, so you can see the favorite and take the best number on either side.
The current spread and total are on the lines board above, priced by the BettorEdge community rather than a house. Because the market is peer-to-peer you can also set your own number and wait for someone to take it.
It is the share of real money posted on each team on the BettorEdge peer-to-peer order book. Because every price is backed by another bettor, the open interest is a genuine read on what the community believes.
Compare the prices on each line above, then take the best number on BettorEdge. BettorEdge is peer-to-peer with no built-in house vig, so it frequently posts a better number than a traditional sportsbook on the same bet.
Yes, the NFL props above are live on BettorEdge. Because the market is peer-to-peer, you can take the posted over/under or set your own number and wait for another user to match it.
Markets lock at kickoff. Prices move as money comes in beforehand, so the community lean and the best number can shift right up until the game starts.
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