USC Trojans vs Indiana Hoosiers odds, spread & prediction
USC Trojans7-2
Indiana Hoosiers8-1Indiana brings one of the stingiest defenses in the Big Ten into Memorial Stadium against a USC offense that has shown it can score on anyone. This is a conference game with real stakes and a clear market lean toward the Hoosiers.
See the full college football board & lines →USC Trojans vs Indiana Hoosiers prediction: who is favored
The market favors the Indiana Hoosiers at -228 on the moneyline, a 69% implied chance to win, and -48.5 on the spread.
BettorEdge community odds as of Nov 8. This is what bettors are pricing, not a pick, and it moves as money comes in.
At a glance
- Indiana is the favorite at -228, USC available at +223 in the markets.
- USC is 7-2, Indiana is 8-1 with the only loss coming to Ohio State.
Lines at a glance
Where this game is priced right now. Every number is peer to peer, set by bettors rather than a sportsbook.
Spread
USC vs Indiana preview
Market Signal and Setting Your Own Number
Neither side has a BettorEdge price posted yet. The fair price in the markets is -228 Indiana and +223 USC. That is exactly where peer-to-peer value lives: if you think the market is off on either side, post your number on BettorEdge and let the community trade against it. No vig means every cent of edge stays in your pocket.
The Matchup
Indiana's defense is the defining story of its 2026 season. The Hoosiers are allowing just 12.4 points per game, a mark that held firm even in losses, and they enter on a two-game winning streak after a road win at Michigan and a home win over Minnesota. USC is averaging 32.4 points per game and just beat Ohio State at home, so this is a genuine test for both sides. The Trojans are also allowing 24.2 points per game, which Indiana's offense has shown it can exploit against good competition.
Common Opponents as a Read
Both teams played Rutgers and Ohio State this season. Against Rutgers, USC won 42-35 on the road while Indiana won 47-15 away. Against Ohio State, USC won 30-18 at home while Indiana lost 15-19 at home. Those results do not decide this game, but they give a like-for-like frame: USC's offense moved the ball freely against Rutgers and knocked off Ohio State, while Indiana's defense has been the more dominant unit against the same opponents.
How the Game Sets Up
Indiana's defense against USC's offense is the lever. The Hoosiers have not allowed more than 23 points in any game this season, and their only loss was by four to Ohio State. USC has not been shut down either, but it dropped a 24-7 decision at Wisconsin in its last road loss. Memorial Stadium in Bloomington gives Indiana an edge, and the market price reflects it. If you believe USC's offense can crack 20-plus against this defense, +223 in the markets offers the value side.
How to play it
Indiana is the clear market favorite and the stronger team by record and defensive metrics, so the number reflects that. The interesting bet is whether USC's scoring ability, 32.4 points per game with a win over Ohio State already banked, is being properly priced against a defense this good.
2026 season so far
Every result both teams have posted this season, with scoring averages.
- vs San José StateW 42-26
- vs Fresno StateW 39-0
- vs LouisianaW 49-30
- at RutgersW 42-35
- vs OregonL 27-41
- vs WashingtonW 25-21
- at Penn StateW 31-23
- at WisconsinL 7-24
- vs Ohio StateW 30-18
Went 9-4 in 2025. Current streak: W1. Home: Los Angeles Memorial Coliseum, Los Angeles, CA.
- vs North TexasW 52-16
- vs HowardW 55-0
- vs Western KentuckyW 38-0
- vs NorthwesternW 29-23
- at RutgersW 47-15
- at NebraskaW 20-17
- vs Ohio StateL 15-19
- at MichiganW 13-6
- vs MinnesotaW 23-16
Went 15-0 in 2025. Current streak: W2. Home: Memorial Stadium, Bloomington, IN.
Common opponents
Teams both sides have already played this season.
- RutgersUSC: W 42-35Indiana: W 47-15
- Ohio StateUSC: W 30-18Indiana: L 15-19
Preseason scouting report
USC Trojans
- New defensive coordinator in Gary Patterson (Baylor Consultant; Former TCU Coach - 2021)
- Jayden Maiava returns at QB after a 2025 season of 3,711 yards (5th in CFB), 24 TDs, and 10 INTs, as well as 157 rushing yards and 6 rushing TDs
- Top two RBs from last season return in King Miller (972 yards, 8 TDs) and Waymond Jordan (576 yards, 5 TDs in 6 games due to injury)
- Top two players in terms of receiving yards from last season are gone, with the top returner being Tanook Hines (561 yards, 2 TDs). NC State transfer WR Terrell Anderson is expected to start (629 yards, 5 TDs), as well as freshman TE Mark Bowman (4-Star Player, #2 TE in Class of 2026 per 247 Sports)
Indiana Hoosiers
- Starting QB from last season is gone. TCU transfer Josh Hoover is expected to start (3,472 yards, 29 TDs, 13 INTs)
- Top two RBs from last season are gone. Boston College transfer Turbo Richard is expected to start (749 yards, 9 TDs)
- Top two players in terms of receiving yards are gone, with the top returner being Charlie Becker (679 yards, 4 TDs). Michigan State transfer Nick Marsh is also expected to start (662 yards, 6 TDs).
- Returning three starting offensive lineman that allowed 25 sacks in 2025 (76th in CFB)
The rest of the slate
Every other Power 5 game with a live market right now.
More college football odds
Frequently asked questions
What time does USC Trojans vs Indiana Hoosiers start?+
USC Trojans at Indiana Hoosiers kicks off Saturday, Nov 14, 3:30 PM ET at Memorial Stadium (Bloomington, IN). Start times are listed in Eastern; check your own zone if you are watching from elsewhere.
Who is favored in USC Trojans vs Indiana Hoosiers?+
The Indiana Hoosiers are favored at -228 on the moneyline in prediction markets and -48.5 on the spread. Prices move as money comes in, and on BettorEdge you can set your own number on either side.
What is the spread for USC Trojans vs Indiana Hoosiers?+
The spread is Indiana Hoosiers -48.5, priced by the BettorEdge community rather than a house. Because the market is peer-to-peer you can also set your own number and wait for someone to take it.
What are USC and Indiana's records in 2026?+
The USC Trojans are 7-2 and the Indiana Hoosiers are 8-1 this season. USC is scoring 32.4 points a game and allowing 24.2; Indiana is scoring 32.4 and allowing 12.4.
What is the "community lean" on this game?+
It is the share of real money posted on each team on the BettorEdge peer-to-peer order book. Because every price is backed by another bettor, the open interest is a genuine read on what the community believes.
When do the lines lock?+
Markets lock at kickoff, Saturday, Nov 14, 3:30 PM ET. Prices move as money comes in beforehand, so the community lean and the best number can shift right up until the game starts.
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