San Francisco 49ers vs Arizona Cardinals
This matchup is not live right now. NFL spreads, totals, the community lean, and player props post as each game approaches. In the meantime:
Matchup history
San Francisco 49ers and Arizona Cardinals last played on Sunday, Sep 27, 2026, when the San Francisco 49ers won 36–30. Over the last 5 meetings: San Francisco 49ers 3, Arizona Cardinals 2.
Sep 27, 2026
ARIArizona Cardinals@
SFSan Francisco 49ers30–36SF
ARIArizona Cardinals@SFSan Francisco 49ers30–36SFNov 16, 2025SFSan Francisco 49ers@ARIArizona Cardinals41–22SF
SFSan Francisco 49ers@ARIArizona Cardinals41–22SFSep 21, 2025ARIArizona Cardinals@SFSan Francisco 49ers15–16SF
ARIArizona Cardinals@SFSan Francisco 49ers15–16SFJan 5, 2025SFSan Francisco 49ers@ARIArizona Cardinals24–47ARI
SFSan Francisco 49ers@ARIArizona Cardinals24–47ARIOct 6, 2024ARIArizona Cardinals@SFSan Francisco 49ers24–23ARI
ARIArizona Cardinals@SFSan Francisco 49ers24–23ARINext scheduled meeting: San Francisco 49ers at Arizona Cardinals on Jan 10, 2027 at 12:00 AM ET. Lines post as the game approaches.
Season so far
Every result for both teams, with points per game for and against.
San Francisco 49ers
6-0
Record
29.5
Points/game
18.3
Allowed/game
Home 4-0. Road 1-0. Current streak: W6.
Results
- vs Los Angeles RamsW 27-7
- vs Miami DolphinsW 35-13
- vs Arizona CardinalsW 36-30
- vs Denver BroncosW 24-14
- at Seattle SeahawksW 32-29
- vs Washington CommandersW 23-17
Arizona Cardinals
2-4
Record
21
Points/game
29.7
Allowed/game
Home 0-2. Road 2-2. Current streak: W1.
Results
- at Los Angeles ChargersW 26-14
- vs Seattle SeahawksL 7-31
- at San Francisco 49ersL 30-36
- at New York GiantsL 24-36
- vs Detroit LionsL 21-45
- at Los Angeles RamsW 18-16
Common opponents
Teams both sides have already played this season.
- Los Angeles RamsSF: W 27-7ARI: W 18-16
- Seattle SeahawksSF: W 32-29ARI: L 7-31