This matchup is not live right now. NFL spreads, totals, the community lean, and player props post as each game approaches. In the meantime:
Los Angeles Rams and San Francisco 49ers last played on Thursday, Sep 10, 2026, when the San Francisco 49ers won 27–7. Over the last 5 meetings: Los Angeles Rams 3, San Francisco 49ers 2.
SFSan Francisco 49ersvs
LARLos Angeles Rams27–7SFLARLos Angeles Rams@SFSan Francisco 49ers42–26LARSFSan Francisco 49ers@LARLos Angeles Rams26–23SFLARLos Angeles Rams@SFSan Francisco 49ers12–6LARSFSan Francisco 49ers@LARLos Angeles Rams24–27LARNext scheduled meeting: Los Angeles Rams at San Francisco 49ers on Dec 13, 2026 at 4:25 PM ET. Lines post as the game approaches.
