This matchup is not live right now. NFL spreads, totals, the community lean, and player props post as each game approaches. In the meantime:
San Francisco 49ers and New York Giants last played on Sunday, Nov 2, 2025, when the San Francisco 49ers won 34–24.
SFSan Francisco 49ers@
NYGNew York Giants34–24SFNext scheduled meeting: San Francisco 49ers at New York Giants on Dec 6, 2026 at 1:00 PM ET. Lines post as the game approaches.
